Table 4.
Organ sample PCR, virus isolation, and neutralizing-antibody test results from the second experiment
Parameter | Value | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Bat | 691 | 680 | 657 | 688 | 677 | 676 | 681 | 679 | 673 | 689 | 678 | 674 |
Dose (TCID50) and route | UIb 104 i.n. | 104 i.n. | 104 i.n. | UI 106 i.n. | 106 i.n. | 106 i.n. | UI 104 s.c. | 104 s.c. | 104 s.c. | UI 106 s.c. | 106 s.c. | 106 s.c. |
Day p.i. euthanized/died | 45 | 45 | 45 | 45 | 25 | 21 | 45 | 45 | 45 | 45 | 45 | 23 |
Organa | ||||||||||||
Reproductive | ||||||||||||
Kidney | × | |||||||||||
Heart | ||||||||||||
Lung | × | × | ||||||||||
Liver | ||||||||||||
Spleen | ○ | × | ||||||||||
Large intestine | × | |||||||||||
Small intestine | ○ | × | ||||||||||
Brain | × | × | ○ | |||||||||
Salivary | ||||||||||||
NAb titerc | <5 | <5 | <5 | <5 | <5 | <5 | <5 | 10 | 10 | <5 | 10 | <5 |
× indicates the sample had detectable TCRV RNA; ○ indicates that viral RNA was detected and virus was isolated on Vero E6 cells; blank indicates that no viral RNA was detected.
UI, uninfected.
NAb, neutralizing antibody.