Fig 10.

Mutation at NDV HN site II abolishes activation of site II in the NDV globular head in the presence of zanamivir. 293T cells expressing the indicated receptor binding proteins (listed on the x axis) were allowed to bind to receptor-bearing RBCs at 4°C in the presence of 5 mM sialyllactose plus 2 mM zanamivir. Values on the y axis reflect percentages of RBCs bound to the glycoprotein-expressing cells, compared with RBCs bound in the absence of inhibitors. The values are means ± SD of results from triplicate monolayers from a representative experiment, repeated 3 times.