Fig 12.

Homology model of HPIV3-NDV HN chimera. Fusion-related conformational changes are relayed from the receptor binding domain to the stalk through the domain interface. The chimeras of HPIV3 HN (yellow and orange) and NDV HN (green and cyan) likely preserve structural elements at the interface that are important for fusion activation. The chimera of HPIV3 HN(1–166)–NDV HN(124–571) has a long linker region (indicated by a dashed line) compared with the HPIV3 HN(1–144) chimera (in solid line) and wt NDV HN.