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Virus replication and spread in IFN-α/βR+/+ or IFN-α/βR−/− mice. Mice were infected intranasally with wtVACV or VACVE3LΔ83N at a dose 10 times the LD50. At 6 days postinfection, the indicated tissues were harvested, and the amount of virus was determined. Error bars represent standard errors of the means within each group (n = 5), and asterisks (**, P < 0.01; *, P < 0.05) indicate samples that are significant, as determined by Student's t tests.
