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A model of divalent recognition by MIR2. Schematic model of B7-2 recognition by MIR2. MIR2 recognizes B7-2 both through the interaction between the MIR2 ITM and the B7-2 JM regions and through the interaction between the MIR2 TM and the B7-2 TM regions. The contribution of the MIR2 ITM and B7-2 JM regions seems larger than that of the MIR2 TM and B7-2 TM regions. After recognition, the MIR2 N-terminal RINGv domain recruits an E2 ubiquitin-conjugating enzyme with activated ubiquitin.
