Fig 1.

Replication of the IL-12-expressing γ₁34.5-deleted HSV M002 is inhibited by acyclovir. In a plaque-reduction assay, M002 was found to have an EC₅₀ of <1.0 μg/ml, similar to its wild-type parent F as well as G207, another γ₁34.5-deleted HSV-1 mutant already used in clinical trials. Shown are the proportions of surviving plaques and standard deviations at various concentrations of acyclovir, relative to infected control cells grown without the drug.