Fig 3.
Survival of B6D2F1 mice following intracranial injection of syngeneic 4C8 murine glioma cells. Fourteen days after tumor implantation, the mice were inoculated with saline (open triangles) or 1 × 107 PFU of either IL-12-expressing M002 (filled circles), IL-4-expressing R8306 (open circles), or the control virus R3659 (filled triangles). Median survival was highest in the M002 treated group (>84 days, P < 0.05), followed by the R3659 group (69 days), saline group (52 days), and the R8306 group (31 days). The R8306 group had the second greatest proportion of long-term survivors after M002.