Fig 4.
Superior efficacy of M002 versus G207 against intracranial human glioma xenografts. SCID mice implanted with D54MG cells were injected 7 days after tumor establishment with 1 × 107 PFU of M002 or G207 or with saline only. Seven days later, mice that received saline were reinjected with saline. Half of the mice that received virus received an additional 5 μl of the same virus, and the other half received 5 μl of saline. Significant differences in median survival times (MST) were as follows: saline/saline versus M002/saline (P = 0.00254), versus M002/M002 (P = 0.000473); M002/saline versus G207/G207 (P = 0.00149); M002/M002 versus G207/G207 (P = 0.0002).