Fig 3.

Three-dimensional (3-D) structure of wild-type and mutant JFH1 NS5B proteins. (A) Close view of loop Λ on the NS5B surface. The sequence conservation on the molecular surface is represented by a blue-white-red gradient. ConSurf conservation scores 1 to 9, representing highly variable to highly conserved residues, and the respective colors are shown below the model (ConSurf server). (B and C) The positions of K151 in the wild type (B) and of R151 in the mutant (C) have been shown in the 3-D model of JFH1 NS5B (PDB identifier, 3i5k) (44). The amino acid sequence of loop Λ2 (shown in purple) and a few surrounding amino acids are given above figure B.