Table 1.

Characteristics of RV NSP4 proteins^a

Group	Length (aa) of:
	Full protein	Hydrophobic domainsb	Putative viroporin domain	Hydrophilic tail
RVA	175	3 (9–21; 29–46; 66–83)	47–90	84–175
RVA (avian)	169	2 (29–46; 66–83)	47–90	84–169
RVB	218–219	3 (6–20; 41–55; 76–84)	61–105	106–219
RVC	150	2 (19–33; 36–55)	33–69	70–150
RVD	127	3 (9–19; 29–46; 52–70)	42–85	71–127
Ungrouped	213	3 (33–41; 51–72; 74–98)	66–106	99–213

^aSummary of NSP4 domain organization of known serogroups.

^bUnderlining indicates predicted transmembrane domains.