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Dose-dependent neutralization graphs of HIV-1 subtype C Env-pseudotyped viruses showing synergism between UCLA1 and T20 or UCLA1 and b12. The aptamer was used at a maximum starting concentration of 50 nM when used alone or in combination. b12 and T20 were used at a maximum initial concentration of 50 μg/ml each and in combination with UCLA1. The 50-μg/ml concentration used for b12 and T20 is equivalent to 312 μM and 1,1131 μM, respectively.
