Fig 3.

Relative contributions (β parameters) of HLA alleles to log VL. (A) All HLA alleles identified at a P value of <0.05 (q < 0.13) in a forward selection procedure; (B) HLA-A and HLA-B alleles, grouped by supertype, that were discordantly association with VL compared to an allele that was associated with differential escape in the same epitope, conditioned on the alleles from panel A. Relative bar heights depict the maximum likelihood β estimates from a joint linear model (estimated corrected average VL among individuals expressing that allele), conditioned on cohort labels. Error bars represent standard error estimates for β.