Table 1.
Cytokine profile during experimental melioidosis in mice treated with control antibody or anti-TGF-βa
| Cytokine/organ | Cytokine level (pg/ml) |
|
|---|---|---|
| Control antibody | Anti-TGF-β | |
| Lungs | ||
| IL-1β | 12,416 ± 1,626 | 9,036 ± 1,540 |
| IL-6 | 14,954 ± 5,050 | 5,037 ± 2,066 |
| IL-17 | 192.9 ± 14.92 | 183 ± 17.86 |
| KC | 18,777 ± 3,996 | 10,524 ± 2,741 |
| MCP-1 | 22,490 ± 3,105* | 13,095 ± 3,049 |
| TNF-α | 4,859 ± 671 | 3,392 ± 628.5 |
| Spleen | ||
| IL-1β | 710 ± 176.6 | 827 ± 79.42 |
| IL-6 | 920.2 ± 453.8 | 111.4 ± 47.73 |
| IL-17 | 62.59 ± 4.21 | 84.58 ± 16.4 |
| KC | 7,300 ± 1,840 | 3,061 ± 514.5 |
| MCP-1 | 3,502 ± 1,824 | 831.8 ± 434.9 |
| TNF-α | 239.7 ± 134.5 | 180.7 ± 92.83 |
a
Mice (n = 8/group) were inoculated with 7.5 × 102 CFU of B. pseudomallei intranasally and treated with anti-TGF-β antibody or control IgG antibody. After 72 h, mice were sacrificed, lungs and spleens were removed and homogenized, and cytokines were measured. Data are expressed as mean ± SEM.
*
, P < 0.05.