Fig. 3.

Scaled schematic representation for a PON1-containing HDL particle

HDL is ~ 10 nm-diameter sphere with a non-polar core of cholesteryl-esters and triglycerides encapsulated in a monolayer of amphipathic α-helical apolipoproteins and phospholipids. Among multiple HDL-associated proteins involved in lipid metabolism, complement regulation, acute-phase response and proteinase inhibition (Vaisar et al., 2007), some of them, durably or transiently associated to PON1-containing HDL and described as having a propensity to contaminate purified PON1 fractions, are shown.