Table 3.
Comparison of genes upregulated during transition to the NC state in the stationary phase (at least 1.5-fold) to the genes activated in other models of persistence
Models of M. tuberculosis persistence | Overlapping to 238 genes activated in the stationary phase during transition to the NC state. | |
Number of genes | % | |
Wayne non-replicating state (Voskuil et al., 2004) | 23 | 9,7 |
Persistence at gradual depletion of carbon source at 50% oxygen tension (Hampshire et al., 2004) | 82 | 34,5 |
Persistence within macrofages (Schnappinger et al., 2003) | 77 | 32,4 |
Artificial granuloma in mice (Karakousis et al., 2004) | 32 | 13,4 |
Enduring hypoxia response (Rustad et al., 2008) | 40 | 16,8 |