Table 3.
The characteristics of crossings at alternation of proliferation and maturation stages during P&D of type 3 Ph+ cells in culture. See notes to Table 2
| N Fig. | N CML patient | Stage alternation scheme | Crossings of accumulation rate plots for proliferating [immature] (stage 1) and maturating cells [mature] (stage 2) | Cell concentration in crossings, 106 cells/ml | |||||||||
| Time of crossing, Day | Stages duration, days | P/D indices in crossing points N | Mature and immature | Segmented (S) | |||||||||
| 1 | 2 | 1 | 2 | 1 | 2 | 3 | 1 | 2 | 1 | 2 | |||
| 1 Fig.3 | 3.1 M | 1/2/1 | 2 | 3,5 | 2 2.5 | 1,5 | 1,1 | 1,2 | - | 0,5 | 0,65 | 0,24 | 0,34 |
| 2 Fig.3 | 3.2 PB | 1/2 | 2,5 | - | 2,5 | >4,5 | 1,06 | - | - | 0,4 | - | 0,1 | - |
| 3 4 | 3.3 BM PB | 1/2 1/2 | 2,5 | 5,5 | 2,5 5,5 | 8,5 5,5 | ~ 2 1,0 | - - | - - | 0,49 0,53 | - - | 0,26 0,38 | - - |
| 5 Fig.3 | 3.4 BM | 1/2/1 | 0,2 | 6 | ~ 0,2 | 5,8 | 1,15 | 1,2 - | 0,37 | 0,8 | 0,17 | 0,58 | |
| 6 | 3.5 BM | 1/2 | 5 | - | 5 | 3 | 1,0 | - | - | 1,53 | - | 0.37 | - |
| 7 | 3.6 BM | 1/2 | 4,5 | - | 4,5 | 3,5 | 1,06 | - | - | 0,53 | - | 0,24 | - |
| 8 9 | 3.7 BM PB | 1/2 1/2/1 | 2,5 2,5-8,5 | 2,5 2,5 | 8,5 8,5 | 1,5 1,2 | - 1,25 | - - | 0,53 0,54 | - 0,4 | 0,4 0,17 | - 0,15 | |
| 10 | 3.8 BM | 1/2 | 5 | - | 5 | >2 | 1,5 | - | - | 0,35 | - | 0,15 | - |
| 11 Fig.4 | 3.10 PB | 2/1- | 3 | - | 4 | 3 | 1,4 | - | - | 0,33 | - | 0,3 | - |
| 12 Fig.4 | 3.11 PB | 2/1/2/1- | 5,5 | 7,5 11 | 2 0 | 5,5 3,5 | 1,15 | 1,15 | 0,80 | 0,75 0,1 | 0,6 | 0,43 0,06 | 0,3 |
| 13 Fig.4 | 3.12 BM | 2/1/2/1/2- | 4,5 | 6 0 8 | 1,5 4,5 | 0 2,5 1 | 1,05 1,0 | 1,0 | 1,0 | 0,62 0,24 | 0,72 0,24 | 0,13 0,34 | 0,35 0,11 |
| 14 | 3.13 PB | 2/1- | 4,0 | 1 4 | 1,7 | - | - | 0,4 | 0,2 | ||||
| 15 | 3.14 BM | 2/1- | 4,0 | 1 4 | 1,0 | - | - | 0,6 | 0,4 | ||||
The mean value of P/D efficiency index at crossings of proliferation and maturation rate plots at alternation stages 1 and 2 is 1.06 ± 0.23 (21,7%). BM - bone marrow, PB- peripheral blood; brackets [ ] show cell concentration; hyphen - interval of values on the kinetic plots; Figure - shows that 1st stages data for alternation 2/1 and 2/1/2/1 are given earlier than that of 2d stages according to the subtitle of the table.