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. 2010 Apr;2(1):111–118.

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Copyright © 2010 Park-media Ltd.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3 — Analysis of the protective hemagglutinin-specific immune response in mice immunized by recombinant Ad-HA5-1 and Ad-HA5-2 adenoviruses and later infected by a lethal dose of avian influenza virus H5N2. (А) Survival of mice infected by a lethal dose (50LD50) of the A/Mallard/ Pensylvania/10218/84H5N2 (H5N2)-strain virus. Mice were immunized twice with the Ad-HA5-1 and Ad-HA5-2 adenoviruses. Control mice were immunized twice either with Ad-null or with PBC solution. The differences in survival between the Ad-HA5-2 (Ad-HA5-1) groups and the PBS control group (р < 0.00001) and the Ad-null control group (p < 0.0001) were statistically significant. (B) Changes in mouse weight as measured for the mice treated with 50LD50 of the A/Mallard/Pensylvania/10218/84H5N2 (H5N2) virus.