Fig. 5.

Analysis of the protective hemagglutinin-specific response in mice immunized by the recombinant Ad-HA5-2 adenovirus and later infected by a lethal dose of either the H1N1 or H3N2 virus. (А) Survival of mice infected with a lethal dose (10LD50) of A/USSR/90/77 (H1N1) or A/Aichi/2/68 (H3N2) influenza virus. Mice were immunized with the Ad-HA5-2 twice in concentration 108 PFU/mouse. Control mice were injected with PBS solution twice. The differences in survival between the Ad-HA5-2 group (infected with H1N1) and the PBS control group were statistically significant, while the differences between the survival in the Ad-HA5-2 group (infected with H3N2) and the PBS control group were not (p = 0.5). (B) Changes in the weight of mice infected with a lethal dose (10LD50) of A/USSR/90/77 (H1N1) or A/Aichi/2/68 (H3N2) virus