Fig. 1.

Schematic presentation of the tyrosinase and melanoma inhibitory activity ( MIA ) promoters. A – scheme of tyrosinase promoter, B – scheme of MIA promoter. The rectangle with diagonal hatching indicates an enhancer, open rectangle indicates the binding site of the transcription factor NF-κB, dark-gray rectangle – the M-box, light-gray rectangle – the E-box, black rectangle – the binding site of the Sp1 factor, a loci corresponding to the minimal promoter is given in parentheses. The arrow shows the transcription start site.