Table 2.

p66 involvement in the development of pathologies associated with oxidative stress and demonstrated on physiological models (experiments with p66shc knockout animals or comparison between young and elderly individuals)

Pathology associated with apoptosis	Organism and genetic line	Reference
Experimental diabetic glomerulopathy	mouse, SV/129	[5]
Vascular cell apoptosis and atherogenesis induced by high-fat diet	mouse, SV/129	[3]
Cardiomyocyte apoptosis in experimental model of diabetes induced by streptozotocin	mouse, SV/129	[31]
Cerebral cortex hypoxia	rat, Sprague–Dawley	[32]