Table 1.

Results of in vitro and cell studies of diketo acid L-731.988 and naphthyridine derivatives L-870.810 and L-870.812 as HIV-1 integration inhibitors

Integrase inhibitor	IC50, in vitro(strand transfer), nM	CIC95ex vivo
L-731.988	8–15 [34]	CIC50 = 1 µM [34]
L-870.810	8–15 [35]	15 nM (10% FBS)100 nM (50% NHS) [36]
L-870.812	40 [36]	250 nM (50% NHS) [37]