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Schematic representation of (A) TRX-tmFGFR3 fusion proteins and (B) expression vectors. Helix – N-terminal fragment of a membrane-active protein from Helicobacter pylori ; TrxA – thioredoxin A of E.coli ; GS – GlySerGlySerGly aminoacid sequence; H6 – hexahistidine sequence; EK – enterokinase light chain cleavage site; tmFGFR3 – target transmembrane peptide from FGFR3 in norma or with Gly380Arg and Ala391Glu single point mutations; Amp r – ampicillin resistance gene.
