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Cartoon of the physiological role of KCa3.1. The channel is activated by increases in intracellular calcium following calcium release from the ER (endoplasmatic reticulum), and/or calcium influx through inward-rectifier calcium channels like CRAC (calcium release activated calcium channel) or TRP (transcient receptor potential) channels. PLC; phospholipase C; IP3 inositol-triphosphate; CAM; calmodulin.
