Fig. 1.

Structure and function of mouse Tet family proteins. The mouse Tet protein family contains three members: Tet1, Tet2 and Tet3. All have a C-terminal CD domain (containing the Cys-rich and DSBH regions) that exhibits 2-oxoglutarate (2-OG)- and iron (II)-dependent dioxygenase activity. The CD domain also includes a spacer region, the length of which varies between Tet family members. The N-termini of Tet1 and Tet3, but not Tet2, contain a CXXC domain, which mediates their direct DNA-binding ability (Zhang et al., 2010; Xu, Y. et al., 2011). There is also a unique PRK12323 (DNA polymerase III subunits gamma and tau; provisional) domain in Tet3. This PRK12323 domain is not assigned to any domain superfamily and its function remains unknown. a.a., amino acids.