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. 2012 Jun 1;139(11):1931–1940. doi: 10.1242/dev.069377

Fig. 2.

Fig. 2.

Wnt5a–/–; Wnt11–/– embryos develop a single-chamber heart. Hematoxylin and Eosin (H+E) staining of histological sections at E9.5 of (Aa-e) Wnt5a+/+; Wnt11+/+, (Ba-e) Wnt5a–/–; Wnt11+/+, (Ca-e) Wnt5a+/+; Wnt11–/– and (Da-e) Wnt5a–/–; Wnt11–/– mouse embryos. Wild type as well as Wnt5a–/– and Wnt11–/– mutants display proper chamber septation. However, Wnt5a–/–; Wnt11–/– mutants lack chamber septation and form a single-chamber heart (question mark in D). Arrows indicate where branchial arch arteries flow into the OFT of the heart. AT, atrium. Scale bar: 150 μm.