Table 1.

Missense mutations of voltage-gated Na⁺ channel subunits identified in Japanese families with febrile seizures associated with afebrile seizures

Patient	Missense mutation
	Nav1.2			Nav1.1	β1
	Exon 1	Exon 4	Exon 10
P1	Arg19Lys	Arg187Trp	Arg524Gln	ND†	ND
	c.56G→A	c.562C→T*	c.1571G→A
P2			Arg524Gln c.1571G→A	A missense mutation in a transmembrane helix‡*	ND
P3, P4, P5, P6	Arg19Lys			ND	ND
	c.56G→A
Control	9/112	0/112	1/162	0/112

^*Bold characters indicate disease mutations. 

^† ND, No mutation was detected. 

^‡ Will be reported elsewhere (36).