Table 1.
Protective effect and liver granuloma size induced by C57BL/6 mice vaccination with CH-DNA nanoparticles and challenged with 25 S. mansoni cercariae.
| Groups | Total worms mean ± SD | Percentage reduction of worm burden | Hepatic granuloma area (μm2) Mean ± SD | Percentage reduction of granuloma area |
|---|---|---|---|---|
| Control | 19.0 ± 2.4 | — | 109743 ± 47427 | — |
| CH | 10.1 ± 0.81* | 47* | 83269 ± 50226 | 24,1 |
| DNA | 13.8 ± 4.5 | 27 | 82352 ± 46222* | 24,9* |
| CHimi-DNA | 16.5 ± 3.6 | 23 | 69085 ± 40416* | 37,0* |
| Chimi-DNA (i.m.) | 17.5 ± 4.1 | 8 | 108222 ± 50046 | 1,39 |
*Statistically significant compared with the control group (P < 0.05).