Table 1.
Baseline clinical characteristics of subjects who participated in the volumetric MRI study (completers) and those who did not participate (non-completers)
| Non-completers (n = 129) | Completers (n = 77) | p value | Participants missing data (n = 206) | |
|---|---|---|---|---|
| Age | 77.0 (71–82) | 76.9 (70–81) | 0.613 | 0 |
| Women | 72 (55.8) | 50 (64.9) | 0.195 | 0 |
| Years of education | 8.5 (7–11) | 8.5 (7–11) | 0.613 | 27 |
| MMSE | 23 (22–26) | 24 (23–26) | 0.230 | 4 |
| AD | 74 (57.4) | 59 (76.6) | 0.005 | 0 |
| DLB/PDD | 42 (32.6) | 12 (15.6) | 0.007 | 0 |
| VaD | 9 (7) | 2 (2.6) | 0.216 | 0 |
| FTD/alcoholic dementia | 4 (3.1) | 4 (5.2) | 0.475 | 0 |
| Mean disease duration (min-max), years | 2.9 (0.5–15) | 2.3 (0.5–12) | 0.045 | 13 |
| Prior depression | 49 (40) | 22 (29) | 0.160 | 7 |
| CIRS total | 6 (4–8) | 6 (4–7) | 0.311 | 2 |
| Use of antipsychotics | 5 (3.9) | 3 (3.9) | 1.000 | 3 |
| Use of anxiolytics/hypnotics | 20 (15.6) | 8 (10.5) | 0.289 | 2 |
| Use of antidepressants | 43 (33.6) | 23 (30.3) | 0.625 | 2 |
| MADRS | 8 (3.3–12.8) | 5 (3–12.5) | 0.446 | 1 |
| MADRS ≥7 | 70 (55) | 33 (43) | 0.135 | 1 |
| MADRS ≥15 | 21 (16) | 14 (18) | 0.892 | 1 |
| APOE∊4 ≥1 allele, fraction (%) | 58/95 (61) | 32/51 (63) | 0.842 | 111 |
Values are median (IQR) or n (%), unless otherwise indicated.
VaD = Vascular dementia; FTD = frontotemporal dementia; MMSE: normal range 24–30; CIRS: range 0 (no impairment)–52 (extremely severe impairment); MADRS: normal range 0–6.
Significant results are shown in bold.