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. 2001 May 15;98(11):6396–6401. doi: 10.1073/pnas.101136398

Figure 5.

Figure 5

G47Δ-infected tumor cells stimulate T cells to a greater extent than G207-infected tumor cells. Human melanoma cells were mock infected (no virus) or infected with G207 or G47Δ at an moi of 3, and after 3–6 h, were cocultured with an equal number of responding human T cells for 18 h. T cell stimulation was assessed by an increase in IFN-γ release into conditioned media. G47Δ-infected melanoma 1102 cells caused a significantly greater stimulation of TIL888 cells compared with G207-infected 1102 cells (P < 0.01, unpaired t test). G47Δ-infected 938 melanoma cells also stimulated TIL1413 cells, although the improvement was not statistically significant compared with G207-infected 938 cells (P = 0.1, unpaired t test). Neither G207- nor G47Δ-infected melanoma 888 cells caused a significant stimulation of TIL888 cells.