Figure 2.

K/BxN serum transfer induced peripheral joint histopathology in WT and Tlr4^−/− mice. (A) Mice were sacrificed 0, 6 and 42 days after arthritis induction and the ankle joints were removed, prepared for histology, sectioned and stained with H&E. x40 original magnification. WT (B) and Tlr4^−/− (C) arthritic mice have prominent inflammation, erosion, and cartilage destruction at day 6 and day 42 which are not statistically different between genotypes.