Table 1.
Number of mice/rats, together with average (± standard deviation) weight, dose of flumazenil and radioactivity administered
| Mice | Rats | |||||
|---|---|---|---|---|---|---|
| Mdr1a/1b | WT | FMZ | FMZ | FMZ | FMZ | |
| dKO | dose 4 μg | dose 20 | dose 100 | dose 400 | ||
| μg | μg | μg | ||||
| Number (n) | ||||||
| Scan 1 | 10 | 9 | 3 | 3 | 2 | 2 |
| Scan 2 | 6 | 6 | 3 | 3 | 2 | 2 |
| Animal weight (g) | 31 ± 2 | 26 ± 2 | 283 ± 24 | 267 ± 11 | 260, 293 | 265, 270 |
| Radioactivity | ||||||
| [11C]FMZ (MBq) | ||||||
| Scan 1 | 7.3 ± 3.0 | 6.5 ± 2.0 | 31 ± 8 | 24 ± 9 | 30, 34 | 18, 20 |
| Scan 2 | 7.0 ± 1.5 | 7.8 ± 2.0 | 21 ± 5 | 18 ± 2 | 16, 26 | 21, 16 |
| Exact FMZ dose | ||||||
| (μg) | ||||||
| Scan 1 | td | td | 3.6 ± 0.1 | 16.3 ± 0.2 | 83, 87 | 366, 424 |
| Scan 2 | td | td | 3.9 ± 0.1 | 17.9 ± 1.0 | 85, 89 | 391, 458 |
Abbreviations: dKO double knockout, WT wild type, FMZ flumazenil, td tracer dose (< 0.1 μg).