The clinical presentations from preschool children with various degrees of caries and/or EHP of HAS-ECC. Panel A shows EHP on multiple primary teeth without active caries that we propose to define as HAS-ECC, stage 0. Panel B shows primary teeth with EHP and a minor to moderate degree of caries that we propose to define as HAS-ECC, stage 1. Panel C shows primary teeth with EHP and severe caries which we propose to define as HAS-ECC, stage 2. These preschool children were from impoverished families, mainly from China, with a documented history of malnutrition (Li et al., 1995). Almost all of them were colonized with moderate to high levels of mutans streptococci (Li et al., 1994).