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. 2012 May 7;209(5):1001–1010. doi: 10.1084/jem.20111675

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© 2012 Barr et al.

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Figure 3. — BCDT is effective only in mice with IL-6–sufficient B cells, irrespective of MOG-reactive antibody levels. (A) Clinical EAE scores of B-WT, IL-6^20%, and B-IL-6^−/− chimeras after anti-CD20 depletion after disease onset (day 10). Curves represent the mean disease scores, with errors bars indicating SEM. Statistical analysis was done by two-way ANOVA, where NS, P > 0.05 and ***, P < 0.001. (B) MOG-specific antibody was quantified by ELISA. Each point represents antibody titer from individual mice, with the bar indicating the mean. Statistical analysis is by Student’s t test, where NS, P > 0.05. Data presented is combined from two independent experiments (n = 6–12).