Table 1.
Differences Between Included Subjects with Vasopressor-Dependent Septic Shock, Excluded Subjects with Vasopressor-Dependent Septic Shock, and Overall Cohort
| Characteristic | Included Patients with Vasopressor-Dependent Septic Shock (n=192) | Excluded Patients with Vasopressor-Dependent Septic Shock (n= 105) | Remainder of cohort (n=1154) | p-value |
|---|---|---|---|---|
| Age, years, mean±SD | 52±16 | 53±18 | 51±17 | 0.37 |
| Male gender | 93 (48) | 49 (47) | 470 (41) | 0.08 |
| Race/Ethnicity | ||||
| White, non-Hispanic | 133 (69) | 70 (67) | 870 (75) | |
| Black | 35 (18) | 22 (21) | 175 (15) | |
| Hispanic | 15 (8) | 8 (8) | 63 (6) | 0.07 |
| Asian/PI | 6 (3) | 5 (5) | 33 (3) | |
| Native American | 0 | 0 | 10 (1) | |
| Other | 3 (2) | 0 | 3 (0.3) | |
| AIDS | 18 (10) | 4 (4) | 62 (5) | 0.08 |
| Leukemia | 4 (2) | 4 (4) | 19 (2) | 0.19 |
| Lymphoma | 3 (2) | 1 (1) | 12 (1) | 0.71 |
| Metastatic cancer | 3 (2) | 4 (4) | 17 (2) | 0.18 |
| Immunosuppression | 22 (12) | 14 (14) | 146 (13) | 0.88 |
| Cirrhosis | 7 (4) | 5 (5) | 33 (3) | 0.38 |
| Diabetes | 38 (20) | 11 (11) | 160 (14) | 0.06 |
| Dialysis-dependent renal failure | 8 (4) | 2 (2) | 28 (3) | 0.37 |
| Pa02:Fi02 ratio, mean±SD | 119 ± 58* | 121 ± 51 | 131 ± 58 | 0.007 |
| APACHE III, mean | 105 ± 33** | 99 ± 27 | 83 ± 29 | <0.0001 |
| Mortality at 28 days | 63 (33)† | 46 (44) | 287 (25) | <0.001 |
| Ventilator-Free Days, median (IQR) | 8 (0, 21)†† | 3 (0, 20) | 16 (0, 24) | 0.0001 |
| Plasma IL-8, pg/ml, median (IQR) | 81 (30, 227)# | 83 (40, 234) | 35 (20, 79) | 0.0001 |
All values represent n (%) unless otherwise specified. Data was missing on 13 subjects for chronic health information, 1 subject for P:F ratio, 9 subjects for ventilator-free days, and 142 subjects for IL-8. Subjects with vasopressor-dependent septic shock were excluded for the following reasons: Use of high tidal volume ventilation, age < 18, or lack of IL-8 data. All p-values below are corrected for multiple comparisons.
Comparison with remainder of cohort: p=0.01; comparison with excluded patients with vasopressor-dependent septic shock: p=1.0
Comparison with remainder of cohort: p<0.001; comparison with excluded patients with vasopressor-dependent septic shock: p=0.39
Comparison with both remainder of cohort and excluded patients non-significant
Comparison with remainder of cohort: p=0.003; comparison with excluded patients with vasopressor-dependent septic shock: p=0.17
Comparison with remainder of cohort: p<0.0001; comparison with excluded patients with vasopressor-dependent septic shock: p=0.4