Table 1. Bone histomorphometry in Ptpn2^−/− (BALB/c) mice.

	Ptpn2+/+ (n = 8)	Ptpn2+/− (n = 4)	Ptpn2−/− (n = 10)	p value +/+ v/s −/−
Femoral length (mm) ± SE	9.5±0.3	9.2±0.2	7.8±0.2	0.002
Femoral width (mm) ± SE	0.93±0.01	0.92±0.04	0.83±0.01	0.002
Trabecular bone volume BV/TV (%) ± SE	4.8±0.6	4.2±0.1	8.9±1.0	0.006
Trabecular number TbN (mm) ± SE	2.4±0.2	2.3±0.4	3.9±0.4	0.006
Trabecular thickness TbTh (µm) ± SE	19.5±0.8	17.4±1.7	23.0±1.1	0.027
Trabecular separation TbSp (µm) ± SE	411±29	462±99	262±30	0.006
Osteoid volume OV/BV (%) ± SE	5.2±1.1	5.0±1.0	2.0±0.5	0.02
Osteoid surface OS/BS (%) ± SE	18.4±2.7	18.2±3.7	12.3±3.0	0.17
Osteoid thickness (µm) ± SE	2.6±0.2	2.4±0.1	1.9±0.1	0.004
Osteoblast surface ObS/BS (%) ± SE	29.7±3.9	27.6±6.1	17.6±4.0	0.04
Osteoclast surface OcS/BS (%) ± SE	21.4±2.5	28.3±6.6	15.3±2. 5	0.08
Number of Osteblasts/Bone perimeter Nob/BPm (/mm) ± SE	18.7±2.0	11.0±4.0	12.0±2.6	0.09
Number of Osteclasts/Bone perimeter Noc/BPm (/mm) ± SE	5.6±0.8	8.5±2. 6	4.1±0.6	0.10

Bone volume/Trabecular bone volume (BV/TV), trabecular number (TbN), trabecular thickness (TbTh) and trabecular separation (TbSp) in 14 day-old Ptpn2^+/+ (BALB/c), Ptpn2^+/− (BALB/c) and Ptpn2^−/− (BALB/c) mice. Osteoid surface/bone surface (OS/BS), osteoid thickness, osteoid volume/bone volume (OV/BV), osteoblast surface/bone surface (ObS/BS), osteoclast surface/bone surface (OcS/BS), number of osteoblasts/bone perimeter (Nob/BPm) and number of osteoclasts/bone perimeter (Noc/BPm) are also shown. Results shown are means ± SEM; p values are for Ptpn2^+/+ versus Ptpn2^−/− mice and were determined using a two-tailed Mann-Whitney U Test.