Table 4. Body composition in 28 day-old Ptpn2ex2−/ex2− and Ptpn2−/− (C57BL/6) mice.
| Ptpn2ex2/ex2 | Ptpn2 (C57BL/6) | |||||
| +/+ (n = 10) | −/− (n = 8) | p value | +/+ (n = 9) | −/− (n = 8) | p value | |
| Lean Mass (g) ±SE | 13.8±0.7 | 5.7±0.5 | 0.0001 | 14.7±1.0 | 6.6±0.5 | 0.0003 |
| Lean Mass/Body Weight (%) ±SE | 81.0±0.7 | 86.0±0.8 | 0.0004 | 85.0±0.7 | 87.0±1.0 | 0.09 |
| Fat Mass (g) ±SE | 3.3±0.2 | 0.9±0.1 | 0.0001 | 2.7±0.3 | 0.9±0.1 | 0.0003 |
| Fat Mass/Body Weight (%) ±SE | 19.3±0.7 | 13.4±0.7 | 0.0001 | 15.2±0.7 | 13.1±1.2 | 0.18 |
| BMC (g) ±SE | 0.19±0.01 | 0.05±0.01 | 0.0001 | 0.23±0.02 | 0.08±0.01 | 0.0006 |
| BMC/Body Weight (%) ±SE | 1.09±0.03 | 0.70±0.13 | 0.06 | 1.29±0.07 | 1.02±0.13 | 0.09 |
| BMD ±SE [BMC(g)/Area (cm2)] | 0.037±0.001 | 0.025±0.001 | 0.0001 | 0.041±0.002 | 0.028±0.001 | 0.0006 |
| BMD/Body Weight (%) | 0.22±0.01 | 0.40±0.04 | 0.0001 | 0.24±0.01 | 0.38±0.01 | 0.0006 |
Body composition [lean, fat, bone mineral content (BMC) and bone mineral density (BMD)] in 28 day-old Ptpn2ex2−/ex2− (C57BL/6) and Ptpn2− /− (C57BL/6) mice and in the corresponding wild type littermates measured by DEXA and normalised to total body weight. Results shown are means ± SEM; p values are for Ptpn2+/+ versus Ptpn2−/− mice and were determined using a two-tailed Mann-Whitney U Test.