Figure 1. α-tocopherol inhibits staurosporine but not camptothecin, TNF-α or etoposide-induced apoptosis.

In all cases, α-tocopherol was added simultaneously to drug treatment. A–D Dose response curves obtained for camptothecin (A), TNF-α supplemented with 10 µM of cycloheximide (CHX) (B), etoposide (C) and STS (D) in response to α-tocopherol treatment (100 µM) in a clone of HeLa cells stably expressing a caspase3/7-differential anchorage probe (C3/7-DAP). E Dose response of STS in a clone of DU145 (prostate carcinoma) expressing a C3/7-DAP was determined in presence or absence of α-tocopherol treatment (100 µM). In each case, EC₅₀ were determined and are presented below the dose-response curves.