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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Curr Opin Pediatr. 2012 Feb;24(1):33–39. doi: 10.1097/MOP.0b013e32834ec106

Table.

Summary description of molecular subtypes of medulloblastoma

Molecular Subtype Approximate percent of patients Typical patient age Typical Histology Cytogenetic markers Molecular markers Clinical strategy
WNT 10% Older childhood Classic Monosomy 6 Beta-catenin Reduction in therapy
SHH 25% Infant and Adult Desmoplastic or Classic 9q loss SFRP1[47]or GAB1[50] SHH pathway inhibitors
Group C 30% Childhood Classic or Anaplastic Isochromosome 17q MYC activation in 50% of this subtype Intensified therapy, novel therapeutics
Group D 35% Childhood Classic or Anaplastic Isochromosome 17q Unknown Research focus needed
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