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. Author manuscript; available in PMC: 2012 Nov 3.
Published in final edited form as: Nature. 2012 May 3;485(7396):133–136. doi: 10.1038/nature10994

Figure 3. L- and D- Shaker peptides block Shaker-IR channels in a similar fashion.

Figure 3

(a) Currents in inside-patches activated with the indicated voltage protocol with (blue) and without (black) 10 μM L-Shaker peptide. (b) Currents with (red) and without (black) 10 μM D-Shaker peptide. (c) Tail currents from (a) at expanded time base. (d) Tail currents from (b) at expanded time base. (a) and (b) are from the same patch. (e) A single Shaker-IR channel was activated and tail currents monitored during application of 100 μM L- or D-Shaker peptides. Bottom panel shows averages of 95 sweeps for no peptide (black), and 105 sweeps for D-(red) and L-peptides (blue). (f) Traces from (e) at higher time resolution. Red bar: time of repolarization. Tail openings after block by D- or L-peptide occur with an average delay of 0.51 ms (97 openings) and 0.57 ms (95 openings), respectively.