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. Author manuscript; available in PMC: 2013 Apr 6.
Published in final edited form as: Drug Resist Updat. 2012 Apr 6;15(1-2):98–105. doi: 10.1016/j.drup.2012.03.002

Fig. 1.

Fig. 1

Scheme demonstrating how chemotherapeutics selectively kill the sensitive (black) sub-population of tumor cells from among a heterogenous malignant population. During the recovery phase multidrug resistant (striped) tumor cells re-populate, and repeated chemotherapeutic cycles result in an intractable multidrug resistant tumor. Treatment with CS agents can kill P-gp-expressing cells and/or reduce P-gp expression, potentially priming tumor cells for treatment with chemotherapeutics.