Table 3.
Model-based functional form and key features of the association between average alcohol intake and risk of ischaemic heart disease, by sex and end point, 1980–2010
| Sex | Stratum | Functional form (x = average alcohol intake, g/day) | No. of Studies | Age at Time of IHD Event, years | Nadir, g/day | Reversion Point, g/daya | P Value for Heterogeneity | I2, % (95% CI) |
|---|---|---|---|---|---|---|---|---|
| Stratified only (n = 24 studies) | ||||||||
| Men | Mortality | log RR = x0.5 + x3 | 17 | 65 | 32 | 63 | <0.001 | 51 (35–63) |
| Morbidity | log RR = x0.5 + ln(x)* x0.5 | 9 | 63 | 69 | - | 0.001 | 46 (21–63) | |
| Women | Mortality | log RR = x + ln(x)* x | 8 | 67 | 11 | 31 | 0.014 | 56 (45–64) |
| Morbidity | log RR = x0.5 + x | 5 | 63 | 14 | 57 | <0.001 | 58 (31–74) | |
| All estimates (n = 44 studies) | ||||||||
| Men | Mortality | log RR = x0.5 + x3 | 34 | 57 | 37 | - | <0.001 | 54 (44–63) |
| Morbidity | log RR = x0.5 + ln(x)* x0.5 | 28 | 56 | 72 | - | <0.001 | 46 (32–58) | |
| Women | Mortality | log RR = x + ln(x)* x | 18 | 58 | 23 | 62 | <0.001 | 51 (34–64) |
| Morbidity | log RR = x0.5 + x | 17 | 63 | 29 | - | <0.001 | 59 (44–69) | |
Abbreviations: CI, confidence interval.
a
Point where the risk function for average alcohol intake turns into a detrimental association with ischaemic heart disease