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SIV-infected macrophages decrease resistance of the BBB model. Addition of SIV-infected macrophages to the upper well (blue) induced a decrease in CI compared with control macrophages (red) or media alone (green, p<0.001). The decrease was mirrored by the addition of TNF-α to the astrocyte face of the CIM plate (B, p<0.001) or the luminal face of the E plates (C, p<0.0001).
