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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Trends Biochem Sci. 2012 Feb 15;37(5):173–178. doi: 10.1016/j.tibs.2012.01.001

Figure 2.

Figure 2

Ligand binding surfaces of SH3 domains. Despite belonging to different proteins, and despite being implicated in different signaling pathways[sta12], the molecular characteristics of SH3 ligand binding surfaces are highly similar. From top to bottom:[sta13] CIN85 (PDB id 2BZ8), Fyn (1SHF), Grb2 C-terminal (2W0Z), Abl (1BBZ). Surfaces are colored according to blue, positively charged atoms; red, negatively charged atoms; green, hydrophobic atoms; salmon, polar oxygens; marine, polar nitrogens; yellow, sulfur.