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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2011 Dec 22;98(0):39–47. doi: 10.1016/j.prostaglandins.2011.12.002

Figure 6. Effect of epoxygenase inhibition or A2A R antagonism on systolic BP of Dahl SR rats after 3 days treatment.

Figure 6

Dahl SR rats on NS diet were pretreated with the epoxygenase inhibitor, MS-PPOH (20 mg/Kg/day), for 3 days prior to switching rats to a HS (2% saline drinking water) intake. After 3 days of HS intake with MS-PPOH treatment, MS-PPOH was withdrawn while rats remained on HS intake for 3 more days. Rats were then switched to NS diet for 7 days. The selective A2A R antagonist, ZM 241385 (5 mg/Kg/day), was then given for 3 days prior to switching rats back to HS intake. ZM 241385 treatment continued during 3 days of HS intake. Data are expressed as means ± SEM; n = 6–7; *** p<0.001 vs. NS.