Table 3.

Biodistribution of ^99mTc-RGD-(Arg¹¹)CCMSH in B16/F1 melanoma-bearing C57 mice. The data was presented as percent injected dose/gram or as percent injected dose (mean ± SD, n=5).

Tissue	0.5 h	2 h	4 h	24 h	2 h NDP Blockade
	Percent injected dose/gram (%ID/g)
Tumor	9.46 ± 1.07	16.12 ± 3.09	12.10 ± 1.45	5.74 ± 1.22	2.55 ± 0.07*
Brain	0.21 ± 0.10	0.05 ± 0.01	0.04 ± 0.01	0.02 ± 0.02	0.05 ± 0.02
Blood	6.10 ± 5.05	0.74 ± 0.34	0.48 ± 0.32	0.08 ± 0.07	0.44 ± 0.37
Heart	3.09 ± 1.13	0.70 ± 0.15	0.31 ± 0.08	0.08 ± 0.03	0.41 ± 0.16
Lung	8.24 ± 2.27	1.54 ± 0.20	0.63 ± 0.29	0.24 ± 0.08	1.13 ± 0.22
Liver	2.73 ± 0.75	2.47 ± 0.20	1.55 ± 0.25	0.65 ± 0.10	1.21 ± 0.24
Skin	7.49 ± 1.75	1.25 ± 0.31	0.53 ± 0.07	0.32 ± 0.13	0.99 ± 0.35
Spleen	1.66 ± 0.25	1.06 ± 0.39	0.66 ± 0.31	0.57 ± 0.25	0.75 ± 0.21
Stomach	4.49 ± 1.59	1.52 ± 0.24	0.85 ± 0.19	0.69 ± 0.25	2.24 ± 0.55
Kidneys	29.34 ± 2.98	23.88 ± 1.45	16.01 ± 2.47	2.80 ± 0.84	13.32 ± 1.68*
Muscle	0.98 ± 0.21	0.20 ± 0.11	0.20 ± 0.02	0.22 ± 0.15	0.24 ± 0.03
Pancreas	1.02 ± 0.52	0.29 ± 0.10	0.20 ± 0.07	0.12 ± 0.07	0.19 ± 0.11
Bone	3.03 ± 0.97	0.92 ± 0.35	0.59 ± 0.18	0.36 ± 0.27	0.59 ± 0.20
	Percent injected dose (%ID)
Intestines	3.80 ± 0.32	1.76 ± 0.37	1.35 ± 0.24	1.22 ± 0.21	3.86 ± 0.84
Urine	29.29 ± 12.36	74.6 ± 4.55	85.92 ± 2.09	90.19 ± 3.25	84.07 ± 1.64
	Uptake ratio of tumor/normal tissue
Tumor/Blood	1.55	21.78	25.21	71.75	5.80
Tumor/Kidneys	0.32	0.68	0.76	2.05	0.19
Tumor/Lung	1.15	10.47	19.21	23.92	2.26
Tumor/Liver	3.47	6.53	7.81	8.83	2.11
Tumor/Muscle	9.65	80.60	60.50	26.09	10.63

^*p<0.05, significance of difference in tumor and renal uptake between ^99mTc-RGD-(Arg¹¹)CCMSH with or without peptide blockade at 2 h post-injection.