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. Author manuscript; available in PMC: 2013 May 10.
Published in final edited form as: J Control Release. 2012 Jan 20;159(3):393–402. doi: 10.1016/j.jconrel.2012.01.009

Figure 7.

Figure 7

Cytotoxicity of different preparations of PTX towards HeLa and 4T1 cells. A and B: HeLa and 4T1 cells were incubated with PL-PTX and TPP-PEG-L-PTX loaded with varied concentration of PTX (the highest PTX dose, 600 ng/mL) for 24 h. C and D: Cells were treated with PTX in different preparations at 650 ng/mL concentration for 48 h. Cell viability was measured at 12, 24 and 48 h. TPP-PEG-L-PTX resulted in significantly greater cytotoxicity than PL-PTX in both the cell lines. Empty PL and TPL used at the same lipid concentration as PL-PTX and TPP-L-PTX (50 µg/mL) were non-toxic (C and D). The data are mean ± SD, averaged from three separate experiments. *, ** and *** indicate p<0.05, p<0.01 and p<0.001 respectively, Student's t-test.

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