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a Pancreatic endocrine tumor with a high expression of nuclear survivin. Dark brown immunoreactivity shows survivin-expressing tumor cell nuclei. Surrounding fibroblast cell nuclei lack survivin and are blue. b Pancreatic endocrine tumor with a low expression of nuclear survivin and abundant expression of cytoplasmic survivin, as indicated by the brown chromogen. Surrounding fibroblast cells lack survivin expression
