Fig. 1.

Study schemas. BID, twice daily. ^a 5 mg BID could be titrated up to 7 mg BID, then 10 mg BID or interrupted/reduced to 3 mg BID, then 2 mg BID. ^b All patients in Study 2 received axitinib at 5-mg, 7-mg and 10-mg single doses on days –5, –3 and –1