Fig. 4.

Effect of antiprogestins on cell cycle distribution in SK-OV-3 cells. Logarithmically growing SK-OV-3 cells were exposed to DMSO (vehicle) or 40 μM RU-38486, ORG-31710 or CDB-2914 for 24 h a, 48 h b, 72 h c or 96 h d. The percentage of events consistent with Sub-G1, G0-G1, S, and G2-M DNA content was analyzed after propidium iodide staining utilizing microcapillary cytometry. The number of cells was recorded at the beginning of the experiment and after different periods of incubation with or without treatments e