Table 1.
Administration of GPO-VIR Z30 tablets per dose by weight groups
| Group | Weight, kg | GPO-VIR Z30, tablets/dose | Children enrolled, n | ZDV dose, mg/m2/daya | 3TC dose, mg/kg/daya | NVP dose, mg/m2/daya |
|---|---|---|---|---|---|---|
| ≥6–8 kg | 6–6.9 | 2 | 4 | 343 (325–367) | 9.1 (8.7–9.9) | 320 (303–343) |
| 7–8 | 3 | 2 | 458 (427–489) | 11.9 (11.3–12.6) | 428 (398–457) | |
| >8–16 kg | >8–11.9 | 3 | 4 | 374 (337–423) | 9.0 (7.9–9.5) | 349 (315–395) |
| 12–16 | 4 | 8 | 391 (355–459) | 8.3 (7.6–9.8) | 365 (331–428) | |
| >16–23 kg | >16–16.9 | 4 | 1 | 334 (334–334) | 7.1 (7.1–7.1) | 312 (312–312) |
| 17–19.9 | 5 | 2 | 410 (393–426) | 8.3 (8.0–8.7) | 383 (367–398) | |
| 20–23 | 6 | 9 | 434 (404–449) | 8.7 (7.9–9.0) | 405 (377–419) | |
| >23–30 kg | >23–24.9 | 6 | 6 | 393 (377–400) | 7.6 (7.2–7.8) | 367 (352–373) |
| 25–30 | 7 | 6 | 419 (402–439) | 7.6 (7.1–8.2) | 391 (375–409) | |
| Overall | − | − | 42 | 403 (325–489) | 8.2 (7.1–12.6) | 376 (303–457) |
a
Values shown are median (range). NVP, nevirapine; ZDV, zidovudine; 3TC, lamivudine.